iminstasis

ikenbot:

Titan as Seen Through 3 Different Filters

On May 15, 2013, Cassini’s camera system, the Imaging Science Subsystem (ISS), looked for clouds across Titan’s sub-Saturn hemisphere from 2.49 million kilometers (1.55 million miles) away.

The ISS took a number of images of Titan in different filters. Three of which were used for this composite image. This RGB false color composite of Titan is in 3 different filters: continuum filter (where methane is more transparent), methane band (where methane is strongly absorbing), and ultraviolet.

Credit: NASA / JPL / SSI / composite by Val Klavans

iwantmoretoys:

Save space in your living room by having your coffee table double as your very own foosball table. When you invite a friend over you’ll have a fun game to play. And the best part of it is that you can rest your drink right on top of the table. And keep score right on top of the table.
http://www.iwantmoretoys.com/foosball-coffee-table

Hahaha my nigga riley

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mareeps:

remember back in like 5th grade when everyone vowed they would never do drugs

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blackfashion:

Naomi Campbell by Mert & Marcus for Interview Russia, December 2012

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gamefreaksnz:

The Warriors come out to play on PSN this month

Rockstar is preparing to release another PlayStation 2 classic on the PlayStation Network.

gamefreaksnz:

Dr. Pikabotnik by victorsbeard

US $11 for 48 hours

Artist: Redbubble | Facebook | Tumblr

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gamefreaksnz:

In the news:

Metal Gear Rising Revengeance Ultimate Edition available now on PlayStation Network
Call of Duty: Ghosts tech comparison video
Batgirl available today as a DLC character in Injustice: Gods Among Us
The Last of Us Hands-On: Lincoln and Pittsburgh
Remedy announces Quantum Break for Xbox One
Forza Motorsport 5 confirmed for Xbox One
Call of Duty: Ghosts gets official reveal trailer
Battlefield 4 confirmed for Xbox One and PS4 
Video: A close-up look at Microsoft’s Xbox One
Microsoft unveils next-gen Xbox One

hangoverpart3:

Catch Alan and the rest of the Wolfpack in the epic conclusion to The Hangover Trilogy – in theaters TODAY! Get tickets: http://hangoverpart3.com 

neurosciencestuff:

Taming suspect gene reverses schizophrenia-like abnormalities in mice

Scientists have reversed behavioral and brain abnormalities in adult mice that resemble some features of schizophrenia by restoring normal expression to a suspect gene that is over-expressed in humans with the illness. Targeting expression of the gene Neuregulin1, which makes a protein important for brain development, may hold promise for treating at least some patients with the brain disorder, say researchers funded by the National Institutes of Health.

Like patients with schizophrenia, adult mice biogenetically-engineered to have higher Neuregulin 1 levels showed reduced activity of the brain messenger chemicals glutamate and GABA. The mice also showed behaviors related to aspects of the human illness. For example, they interacted less with other animals and faltered on thinking tasks.

“The deficits reversed when we normalized Neuregulin 1 expression in animals that had been symptomatic, suggesting that damage which occurred during development is recoverable in adulthood,” explained Lin Mei, M.D., Ph.D.External Web Site Policy , of the Medical College of Georgia at Georgia Regents University, a grantee of NIH’s National Institute of Mental Health (NIMH).

Mei, Dong-Min Yin, Ph.D., Yong-Jun Chen, Ph.D., and colleagues report on their findings May 22, 2013 in the journal Neuron.

“While mouse models can’t really do full justice to a complex brain disorder that impairs our most uniquely human characteristics, this study demonstrates the potential of dissecting the workings of intermediate components of disorders in animals to discover underlying mechanisms and new treatment targets,” said NIMH Director Thomas R. Insel, M.D. “Hopeful news about how an illness process that originates early in development might be reversible in adulthood illustrates the promise of such translational research.”

Schizophrenia is thought to stem from early damage to the developing fetal brain, traceable to a complex mix of genetic and environmental causes. Although genes identified to date account for only a small fraction of cases, evidence has implicated variation in the Neuregulin 1 gene. For example, postmortem studies have found that it is overexpressed in the brain’s thinking hub, or prefrontal cortex, of some people who had schizophrenia. It codes for a chemical messenger that plays a pivotal role in communication between brain cells, as well as in brain development.

Prior to the new study, it was unclear whether damage caused by abnormal prenatal Neuregulin 1 expression might be reversible in adulthood. Nor was it known whether any resulting behavioral and brain deficits must be sustained by continued errant Neuregulin 1 expression in adulthood.

To find out, the researchers engineered laboratory mice to mimic some components of the human illness by over-expressing the Neuregulin 1 gene in the forebrain, comparable to the prefrontal cortex in humans. Increasing Neuregulin 1 expression in adult animals was sufficient to produce behavioral features, such as hyperactivity, social and cognitive impairments, and to hobble neural communications via the messenger chemicals glutamate and GABA.

Unexpectedly, the abnormalities disappeared when the researchers experimentally switched off Neuregulin 1 overexpression in the adult animals. Treatment with clozapine, an antipsychotic medication, also reversed the behavioral abnormalities. The researchers traced the glutamate impairment to an errant enzyme called LIMK1, triggered by the overexpressed Neuregulin 1 — a previously unknown potential pathological mechanism in schizophrenia.

The study results suggest that even if their illness stems from disruptions early in brain development, adult patients whose schizophrenia is rooted in faulty Neuregulin 1 activity might experience a reduction in some of the symptoms following treatments that target overexpression of the protein, say the researchers.

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asthetiques:

Gold Painted Stripper Photo by Weegee (Arthur Fellig) (1950)

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